Lonazolac calcium

subject:Lonazolac calcium
Chemical Structure:
Title:Underhalt, B.
Source:Drugs Fut 1982,7(2),110

Drug Preparation:
The pyrazole-4-carbaldehyde (I) synthesized according to Vilsmeier is reduced to the alcohol (II), which is chlorinated to (III). (III) is reacted with sodium cyanide to give the nitrile (IV), which is hydrolyzed to lonazolac (V). The calcium salt, slightly soluble in water, is formed by adding calcium chloride to (V).
References:No.604479
Title:Synthese und physikalisch-chemische Eigenschaften von Lonazolac-Ca, einem neuen Antiphlogistikum / Antirheumatikum
author:Rainer, G.; Krüger, U.; Klemm, K.
Source:Arzneim-Forsch Drug Res 1981,31(4),649

Drug Preparation:
The pyrazole-4-carbaldehyde (I) synthesized according to Vilsmeier is reduced to the alcohol (II), which is chlorinated to (III). (III) is reacted with sodium cyanide to give the nitrile (IV), which is hydrolyzed to lonazolac (V). The calcium salt, slightly soluble in water, is formed by adding calcium chloride to (V).